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NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: Our previous study found that overexpression of gene in PC3 cell line could slow down the tumor proliferation

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter    

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Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 280-288 doi: 10.1007/s11684-017-0580-1

Abstract:

Lung squamous cell carcinoma (LUSC) causes approximately 400 000 deaths each year worldwide.However, few studies have investigated the genomic variations that occur only in normal tissues thatsquamous cell carcinomas.We then called genomic variations specific to the normal lung tissues through filtering the genomic sequenceSixteen genomic variations were called in the three normal lung tissues.

Keywords： lung cancer     counterpart normal control     genomic variations    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract:

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an importantDepending on the contextual signals and intracellular gene circuits of a particular cell, this programcan drive fully epithelial cells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymalThese cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistanceoverview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: In this study the effects of lipopolysaccharide (LPS) and interleukin-10 (IL-10) on the formation ofMacrophage was induced by phorbol myristate acetate (PMA) treatment on THP-1 cells.The ratio of foam cell formation was increased from (9.77 ± 1.70)% to (16.27 ± 2.27)% after 24 h stimulationThis study demonstrates that ox-LDL can cause foam cell formation from macrophages .These results indicate that inflammatory effects in blood vessels can speed up foam cell formation.

Keywords： inflammatory     presence     interleukin-10     dose-dependent     ox-LDL    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: , we generated new mouse models with Axin1 conditional knockout in intestinal epithelial cell(IEC; Axin1ΔIEC) and Paneth cell (PC; Axin1ΔAxin1ΔIEC mice exhibited altered goblet cell spatial distribution, PCepithelial Axin1 and Axin1-associated A. muciniphila.Further mechanistic studies using specific Axin1 mutations elucidating how Axin1 modulates the microbiome

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitsIn particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCcompared with that in their counterpart normal kidney tissues.Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worsetranscription factors c-FOS and GATA1, which were identified by data mining.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library Article

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Engineering 2021, Volume 7, Issue 11,   Pages 1557-1565 doi: 10.1016/j.eng.2020.11.011

Abstract:

Immunotherapy with anti-programmed cell death protein-1 (PD-1)/programmed cell death ligandThe PD-1/PD-L1 pathway inhibits T cell activation in the micro-environment, making it an(Opdivo), a small-content, epitope-oriented mammalian cell library was established for PD-1.The 463 decoy mutant reversed the inhibitory function of PD-1 in T cell activation; furthermore, 10 effect than 10 mg·kg−1 of WT PD-1.

Keywords： Decoy PD-1     PD-L1     Mammalian cell library     Epitope-oriented    

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Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymalThe expressions of E-cadherin (E-Cad), N-cadherin (N-Cad), vascular endothelial cell growth factor (VEGF

Keywords： epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9    

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A replenishment for resource reserves：functional reserves— Replacing 1/10~1/5 strategic oil reserve with

Jin Yong,Chen Bingzhen

Strategic Study of CAE 2008, Volume 10, Issue 11,   Pages 4-6

Abstract:

The strategic oil reserve is very important for every large country in the world. In order to meet the basic requirement of the state safety, 3 months strategic oil reserve in every large country was proposed by the different international organizations such as UN, EU, etc. For China, the total amount of strategic oil reserve must be up to about 30 to 90 millions. It is very difficult to achieve it without enormous capita in short time. Based on a new conception as "function reserve" to replenish the "resource reserve", this goal could be more easy to be accomplished.Namely, storing more methanols replaces some percentage of oil. Moreover, the state safety should be ensured. This topic is discussed in the article in detail.

Keywords： function store     strategical oil store     methanol    

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Technological Approaches to Increasing Specific Power of Vehicular Fuel Cell Stacks

Hou Ming, Shao Zhigang, Yi Baolian

Strategic Study of CAE 2019, Volume 21, Issue 3,   Pages 84-91 doi: 10.15302/J-SSCAE-2019.03.002

Abstract: Fuel cell stack is the core of a fuel cell vehicle, and specific power indicates the technical levelof a fuel cell stack.Using a high-specific-power fuel cell stack technology, the number of stack hardware can be reduced,specific power.In this paper, the technical approaches to improving the specific power of the fuel cell stack are discussed

Keywords： fuel cell vehicle     fuel cell stack     performance     specific power    

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Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 304-316 doi: 10.1007/s11684-022-0964-8

Abstract: The structure of N-glycans on specific proteins can regulate innate and adaptive immunity viastructural diversity of N-glycans poses analytical challenges that limit the exploration of specificmass spectrometry (MS)-based glycoproteomic approaches, followed by the large-scale mapping of site-specific/sub>Neu5Ac1, N4H5F1S1) were increased in M1 andThe precision structural interpretation of site-specific glycans and subsequent intervention of target

Keywords： macrophage     glycoproteome     glycopeptides     N-glycan structures     PD-L1    

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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract: , while S100A10 transcripts remained constitutive.subunit, although S100A10 transcripts remained constitutive.tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cellzinc-induced U937/PR9 or circulating APL blasts with all-trans retinoic acid (ATRA) significantly reduced cellsurface ANXA2 and S100A10 and associated reductions in IRPG and invasiveness.

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 486-491 doi: 10.1007/s11684-013-0287-x

Abstract: Human nasal mucosa of the uncinate process was obtained by endoscopy and epithelial cell cultures wereEpithelial cell growth characteristics were observed by inverted phase contrast microscopy.Ciliated cell differentiation was detected by β-tubulin IV and ZO-1 immunocytochemistry.In both culture systems, the highest ciliated cell density appeared at 7th–10th culture day andOverall, 10% of the cells in explant cultures and 20% of the cells in the dissociated tissue cultures

Keywords： ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isa cell surface receptor expressed on monocytes/macrophages and neutrophils.TREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway.Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluidsis a more sensitive and specific biomarker than traditional indices, such as C-reactive protein and procalcitonin

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: for developing more effective therapies that target highly tumorigenic and drug-resistant cancer stem celldemonstrate that a subset of cancer cells with CSC properties may be enriched into tumor spheroids under stem cellconditions from a non-small cell lung cancer cell line.Treating these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK100477736 enhances the anti-proliferative effect of gemcitabine against both the parental and the CSC-like cell

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Title Author Date Type Operation

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Journal Article

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article

A replenishment for resource reserves：functional reserves— Replacing 1/10~1/5 strategic oil reserve with

Jin Yong,Chen Bingzhen

Journal Article

Technological Approaches to Increasing Specific Power of Vehicular Fuel Cell Stacks

Hou Ming, Shao Zhigang, Yi Baolian

Journal Article

Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Journal Article

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Journal Article

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article